Olfactory receptor-based CNT-FET sensor for the detection of DMMP as a simulant of sarin

Dimetyl metylphosphonate (DMMP) is a simulant of sarin, which representative nerve agents. Sarin an organophosphorus toxic compound that inhibitor acetylcholinesterase, paralyzing human neurotransmission and the autonomic nervous system. Detection these agents has been considered important for safety issues to prevent terrorism counter military threats. Although there have various studies on sensors detecting DMMP as limitations still exist in specificity, sensitivity, reliability. To overcome limitations, we utilized olfactory receptor (hOR)-based single-walled carbon nanotube-field effect transistor (swCNT-FET) platform detection DMMP. The hORs high specificity their certain target molecules. swCNT-FET can also convert biological signals electrical with sensitivity. By screening hORs, hOR2T7 selectivity was selected, it produced development hOR2T7-conjugated bioelectronic nose (hOR2T7 B-nose). A B-nose able selectively detect at concentration 10 fM. This shows ultrasensitive selective performance tool sensing chemical warfare (CWAs), could be used practical applications field safety.